Our Human Variability - A Conversation with Stephen Scherer

by Howard Burton (Author)
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This book is based on an in-depth filmed conversation between Howard Burton and Stephen Scherer, the GlaxoSmithKline Research Chair in Genome Sciences at the Hospital for Sick Children and University of Toronto. Stephen Scherer discusses his lifelong passion for science that culminated in his groundbreaking discovery of copy-number variation. This conversation also covers his exciting work in autism research and how copy number variation brings us a deeper understanding of both human variability and disease.

This carefully-edited book includes an introduction, More Things in DNA, Horatio..., and questions for discussion at the end of each chapter:

I. James Watson’s Legacy - From The Double Helix to NRC to chromosome 7
II. In the Lab - The first hints of copy number variation
III. Chromosome 7 - Mapping genetic markers to chromosomes
IV. Back to Basics - Nucleotides, DNA, chromosomes, genes and mutations
V. Revolutionary Stirrings - Detecting copy number variation
VI. Going Global - Large-scale variation for all
VII. Variability and Evolution - Appreciating biological variability
VIII. Causes and Implications - Complexity galore: autism and other conditions
IX. Towards Treatment - Early diagnoses and equilibrium-restoring medicines
X. The Definition of Diseases - More complicated that you might think
XI. Probing Deeper - Stem cells, pleiotropy and environmental factors
XII. Ethical and Societal Issues - Towards responsible progress
XIII. Future Possibilities - Potentially unravelling biological complexity
XIV. Contact with Autism - Serendipitous occurrences
XV. Nobel Thoughts - The perks and perils of prizes
XVI. The Human Condition - Genetic windows on humanity

About Ideas Roadshow Conversations Series:

This book is part of an expanding series of 100+ Ideas Roadshow conversations, each one presenting a wealth of candid insights from a leading expert through a focused yet informal setting to give non-specialists a uniquely accessible window into frontline research and scholarship that wouldn't otherwise be encountered through standard lectures and textbooks. For other books in this series visit our website: https://ideasroadshow.com/.

Publication date
September 30, 2020
File size
2 MB