Un-Usual People is a part-memoir, part-instructional manual consisting of evidence-based premises, patient and caregiver stories, suggestions on required knowledge and skills, and solutions used in the art and act of providing healthcare. The subjects are a combination of regular and special-needs patients who seek and receive medical attention, diagnoses and therapies and the caregivers and healthcare personnel who provide the CARE. The ability to Communicate, connect, and cooperate, Accept and appreciate, Relate and explain, Energize and encourage comprise the acronym of effective healthcare. How patients are treated and behave, plays a major role in the response to medical care and the final outcomes. Honesty, cooperation, positive attitude, trust, adherence to the treatment plan and appreciation are essentials for the patients. Open and sincere communication, hope, skill, and knowledge are the working instruments of healthcare delivery. The basic premise is that every human being has value and deserves to be treated with respect.